Reprogramming cellular events by poly(ADP-ribose)-binding proteins

Poly(ADP-Ribose) Polymerase 1: Cellular Pluripotency, Reprogramming, and Tumorogenesis

Poly(ADP-ribos)ylation (PARylation) is the catalytic function of the Poly(ADP-ribose) polymerases (Parps) family for post-translational modification in cellular process. Being a major member of Parps, Parp1 is a crucial nuclear factor with biological significance in modulating DNA repair, DNA replication, transcription, DNA methylation and chromatin remodeling through PARylation of downstream p...

PolyADP-Ribosylation in Postfertilization and Genome Reprogramming: Implications for Carcinogenesis

Reprogramming cellular behavior with RNA controllers responsive to endogenous proteins.

Synthetic genetic devices that interface with native cellular pathways can be used to change natural networks to implement new forms of control and behavior. The engineering of gene networks has been limited by an inability to interface with native components. We describe a class of RNA control devices that overcome these limitations by coupling increased abundance of particular proteins to tar...

Metabolic reprogramming by KSHV in cellular transformation

Oncogenic Kaposi’s sarcoma-associated herpesvirus (KSHV) is causally linked to several human cancers including Kaposi’s sarcoma and primary effusion lymphoma. Despite intensive studies, little is known about how KSHV alters cellular metabolism during cellular transformation. Using a novel model of KSHV-induced cellular transformation of primary rat embryonic metanephric mesenchymal stem cells (...

I-10: Transcriptomics in Oocyte Mediated Cellular Reprogramming

a:4:{s:10:"Background";s:1707:"Early embryonic development in mammals begins in transcriptional silence with an oocyte-mediated transcriptional reprogramming of parental gametes occurs during a so called across-the-board process of “erase-and-rebuild”. In this process, the parental transcription programs are erased long before (maternal) or soon thereafter (paternal) fertilization to generate a...